Article
Association between IL-17F gene polymorphisms and susceptibility to and severity of rheumatoid arthritis (RA).
Scandinavian journal of immunology - 1 Aug 2010
Paradowska-Gorycka A, Wojtecka-Lukasik E, Trefler J, Wojciechowska B, Lacki J K, Maslinski S
Abstract excerpt
Interleukin-17F (IL-17F) is a novel proinflammatory cytokine. IL-17F gene is an excellent candidate for chronic inflammatory disease. We investigated the association between rheumatoid arthritis (RA) and His161Arg (7488A/G; rs763780) and Glu126Gly (7383A/G; rs2397084) polymorphism of IL-17F gene. The gene polymorphisms in 220 Polish patients with RA and 106 healthy subjects were amplified by polymerase chain...
Topics
- Age of Onset
- Arthritis, Rheumatoid
- Chi-Square Distribution
- DNA
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Humans
- Interleukin-17
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single Nucleotide
- Severity of Illness Index