Article
Significant association between IL-17F promoter region polymorphism and susceptibility to asthma in a Korean population.
International archives of allergy and immunology - 1 Jan 2011
Jin Eun-Heui, Choi Eun-Young, Yang Ji Yeon, Chung Hun-Taeg, Yang Yun-Sik
Abstract excerpt
BACKGROUND: Individual differences in susceptibility to asthma would be expected because of common DNA variants of single nucleotide polymorphisms (SNPs) across populations. The pro-inflammatory cytokine IL-17F has homology with the IL-17 motif and induces the expression of other inflammatory cytokines in airway epithelial cells. This study aimed to identify IL-17F gene polymorphisms and to determine a possible...
Topics
- Asthma
- DNA Mutational Analysis
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin-17
- Korea
- Male