Article
Repeated exposure to Ochratoxin A generates a neuroinflammatory response, characterized by neurodegenerative M1 microglial phenotype.
Neurotoxicology - 1 Sept 2014
von Tobel Jenny Sandström, Antinori Paola, Zurich Marie-Gabrielle, Rosset Robin, Aschner Michael, Glück Florent, Scherl Alexander, Monnet-Tschudi Florianne
Abstract excerpt
Neurotoxic effects of the environmentally abundant mycotoxin Ochratoxin A (OTA) were studied in histotypic 3D rat brain cell cultures, comprising all brain cell types. Cultures were exposed to nanomolar OTA concentrations and samples were collected 48h after a single exposure, or after 10 days of repeated administration. OTA-induced changes in gene- and protein expression, as well as alterations in cell...
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