Article

4-HNE reduces phagocytosis through the expression of Synaptotagmin 1 in human monocyte-derived macrophages

2025-11-25

Abstract excerpt

Reactive oxygen species (ROS) react with polyunsaturated fatty acids (PUFA) and generate the reactive aldehyde 4-hydroxynonenal (4-HNE). 4-HNE is a potent modulator of cell signaling, proliferation, and death. Our transcriptomics analysis revealed that upon treatment of human monocyte-derived macrophages with 4-HNE synaptotagmin-1 (SYT1), the main calcium sensor for neurotransmitter release, became the most strong...

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Literature Corpus work: 3b8cda84-18dd-5b6f-bf5f-cca3cc7f9af0
DOI: 10.1101/2025.11.24.690103

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