Isolation and Characterization of Microglia from Adult Mouse Brain: Selected Applications for <i>ex Vivo</i> Evaluation of Immunotoxicological Alterations Following <i>in Vivo</i> Xenobiotic Exposure

Abstract excerpt

Microglia play a dual role in neuroprotection as well as in neurodegeneration and thus occupy the focal interest in neurodegenerative disease research. In vitro studies either by using cell lines or neonatal mouse primary microglia correlated xenobiotic induced microglial activation and neuronal death. However, these in vitro studies cannot portray the in vivo scenario. Therefore, environmental pollutant induced...

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