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Article

CD4+ T cell-associated cytokines induce a chronic pro-inflammatory phenotype in induced pluripotent stem cell-derived midbrain astrocytes.

Glia - 1 Nov 2024

MacMahon Copas Adina N, McComish Sarah F, Petrasca Andreea, McCormack Rachel, Ivers Daniel, Stricker Anna, Fletcher Jean M, Caldwell Maeve A

Abstract excerpt

Astrocytes are mediators of homeostasis but contribute to neuroinflammation in Parkinson's disease (PD). Mounting evidence suggests involvement of peripheral immune cells in PD pathogenesis. Therefore, this study aimed to determine the potential role of peripheral immune secreted cytokines in modulating midbrain astrocyte reactivity. Human iPSC-derived midbrain astrocytes were exposed to 5% and 10% CD4+ T cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39056451
DOI: 10.1002/glia.24601

Genes

TNF
CD4
CXCL10
C3
LCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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