Article
Brain white matter development is associated with a human-specific haplotype increasing the synthesis of long chain fatty acids.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Apr 2014
Peters Bart D, Voineskos Aristotle N, Szeszko Philip R, Lett Tristram A, DeRosse Pamela, Guha Saurav, Karlsgodt Katherine H, Ikuta Toshikazu, Felsky Daniel, John Majnu, Rotenberg David J, Kennedy James L, Lencz Todd, Malhotra Anil K
Abstract excerpt
The genetic and molecular pathways driving human brain white matter (WM) development are only beginning to be discovered. Long chain polyunsaturated fatty acids (LC-PUFAs) have been implicated in myelination in animal models and humans. The biosynthesis of LC-PUFAs is regulated by the fatty acid desaturase (FADS) genes, of which a human-specific haplotype is strongly associated with ω-3 and ω-6 LC-PUFA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.