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Brain tissue- and cell type-specific eQTL Mendelian randomization reveals efficacy of FADS1 and FADS2 on cognitive function.

Translational psychiatry - 5 Feb 2024

Wu Xueyan, Jiang Lei, Qi Hongyan, Hu Chunyan, Jia Xiaojing, Lin Hong, Wang Shuangyuan, Lin Lin, Zhang Yifang, Zheng Ruizhi, Li Mian, Wang Tiange, Zhao Zhiyun, Xu Min, Xu Yu, Chen Yuhong, Zheng Jie, Bi Yufang, Lu Jieli

Abstract excerpt

Epidemiological studies suggested an association between omega-3 fatty acids and cognitive function. However, the causal role of the fatty acid desaturase (FADS) gene, which play a key role in regulating omega-3 fatty acids biosynthesis, on cognitive function is unclear. Hence, we used two-sample Mendelian randomization (MR) to estimate the gene-specific causal effect of omega-3 fatty acids (N = 114,999) on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38316767
DOI: 10.1038/s41398-024-02784-4
PMCID: PMC10844634

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