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Article

Genetic adaptation of fatty-acid metabolism: a human-specific haplotype increasing the biosynthesis of long-chain omega-3 and omega-6 fatty acids.

American journal of human genetics - 4 May 2012

Ameur Adam, Enroth Stefan, Johansson Asa, Zaboli Ghazal, Igl Wilmar, Johansson Anna C V, Rivas Manuel A, Daly Mark J, Schmitz Gerd, Hicks Andrew A, Meitinger Thomas, Feuk Lars, van Duijn Cornelia, Oostra Ben, Pramstaller Peter P, Rudan Igor, Wright Alan F, Wilson James F, Campbell Harry, Gyllensten Ulf

Abstract excerpt

Omega-3 and omega-6 long-chain polyunsaturated fatty acids (LC-PUFAs) are essential for the development and function of the human brain. They can be obtained directly from food, e.g., fish, or synthesized from precursor molecules found in vegetable oils. To determine the importance of genetic variability to fatty-acid biosynthesis, we studied FADS1 and FADS2, which encode rate-limiting enzymes for fatty-acid...

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Identifiers

PMID: 22503634
DOI: 10.1016/j.ajhg.2012.03.014
PMCID: PMC3376635

Genes

FADS1
FADS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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