Article
Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2014
Rinne Petteri, Silvola Johanna M U, Hellberg Sanna, Ståhle Mia, Liljenbäck Heidi, Salomäki Henriikka, Koskinen Emilia, Nuutinen Salla, Saukko Pekka, Knuuti Juhani, Saraste Antti, Roivainen Anne, Savontaus Eriika
Abstract excerpt
OBJECTIVE: Melanocortin peptides have been shown to elicit anti-inflammatory actions and to promote vascular endothelial function by activating type 1 and 3 melanocortin receptors. Here, we addressed whether these favorable properties of melanocortins could reduce atherosclerotic plaque inflammation and improve vasoreactivity in atherosclerotic mice. APPROACH AND RESULTS: Low-density lipoprotein...
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