Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2011

Silvola Johanna M U, Saraste Antti, Forsback Sarita, Laine V Jukka O, Saukko Pekka, Heinonen Suvi E, Ylä-Herttuala Seppo, Roivainen Anne, Knuuti Juhani

Abstract excerpt

OBJECTIVE: Atherosclerotic plaques with large lipid cores and inflammation contain regions of hypoxia. We examined the uptake of 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide ([18F]EF5), a specific marker of hypoxia labeled for positron emission tomography, in mouse atherosclerotic plaques. METHODS AND RESULTS: Atherosclerotic mice of 2 different genetic backgrounds (low-density...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Apolipoprotein B-100

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Autoradiography

Share to Hypoxia

Share to Insulin-Like Growth Factor II

Share to Nitroimidazoles

Share to Positron-Emission Tomography

Share to Radiopharmaceuticals

Source

Identifiers

PMID: 21372297
DOI: 10.1161/ATVBAHA.110.221440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.PMID 21372297Read ↗

Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal ModelsSemantic proximity Read ↗

Emergence of targeted molecular imaging in atherosclerotic cardiovascular disease.Semantic proximity Read ↗

Autoradiographical assessment of inflammation-targeting radioligands for atherosclerosis imaging: potential for plaque phenotype identificationSemantic proximity Read ↗

Contrast-Enhanced, Molecular Imaging of Vascular Inflammation in the Mouse Model by Simultaneous PET/MRISemantic proximity Read ↗

Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [18F]FDG uptake in Ldlr-/-Apob100/100 mice.Semantic proximity Read ↗

In Vivo ¹⁸F-FDG-PET Imaging in Mouse Atherosclerosis.Semantic proximity Read ↗

18F-FDG PET Imaging of Murine Atherosclerosis: Association with Gene Expression of Key Molecular MarkersSemantic proximity Read ↗

Imaging of Atherosclerosis with [64Cu]Cu-DOTA-TATE: a Translational Head-to-Head Comparison Study with 2-[18F]FDG, and Na[18F]F in RabbitsSemantic proximity Read ↗

Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging.Semantic proximity Read ↗

Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomographySemantic proximity Read ↗

EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis.Semantic proximity Read ↗

Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.