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Article

NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2017

van der Heijden Thomas, Kritikou Eva, Venema Wouter, van Duijn Janine, van Santbrink Peter J, Slütter Bram, Foks Amanda C, Bot Ilze, Kuiper Johan

Abstract excerpt

OBJECTIVE: Inflammasomes are multiprotein complexes, and their activation has been associated with cardiovascular disease. Inflammasome activation leads to secretion of caspase-1 by innate immune cells, resulting in the activation of interleukin-1β. Recently, a potent and selective inhibitor of the NLRP3 inflammasome, MCC950, was described. In this study, we investigated the effect of MCC950 on atherosclerotic...

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Identifiers

PMID: 28596375
DOI: 10.1161/ATVBAHA.117.309575

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NLRP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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