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Article

Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [18F]FDG uptake in Ldlr-/-Apob100/100 mice.

Atherosclerosis - 1 Aug 2017

Hellberg Sanna, Sippola Suvi, Liljenbäck Heidi, Virta Jenni, Silvola Johanna M U, Ståhle Mia, Savisto Nina, Metso Jari, Jauhiainen Matti, Saukko Pekka, Ylä-Herttuala Seppo, Nuutila Pirjo, Knuuti Juhani, Roivainen Anne, Saraste Antti

Abstract excerpt

BACKGROUND AND AIMS: Uptake of the positron emission tomography (PET) tracer 2-deoxy-2-[18F]-fluoro-d- glucose ([18F]FDG) into macrophages is a sensitive marker of inflammation in atherosclerosis. To assess the anti-inflammatory effects of statins, we studied whether atorvastatin therapy reduces aortic [18F]FDG uptake in hypercholesterolemic mice deficient in low-density lipoprotein receptor (Ldlr), and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28457625
DOI: 10.1016/j.atherosclerosis.2017.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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