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Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2014

Hayashi Takeshi, Ebe Masahiro, Nagao Koji, Kokubu Aya, Sajiki Kenichi, Yanagida Mitsuhiro

Abstract excerpt

CENP-A is a centromere-specific variant of histone H3 that is required for accurate chromosome segregation. The fission yeast Schizosaccharomyces pombe and mammalian Mis16 and Mis18 form a complex essential for CENP-A recruitment to centromeres. It is unclear, however, how the Mis16-Mis18 complex achieves this function. Here, we identified, by mass spectrometry, novel fission yeast centromere proteins Mis19 and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 24774534
DOI: 10.1111/gtc.12152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.PMID 24774534Read ↗

Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.Semantic proximity Read ↗

Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.Semantic proximity Read ↗

Subunit interactions and arrangements in the fission yeast Mis16-Mis18-Mis19 complex.Semantic proximity Read ↗

The chromodomain protein Swi6: a key component at fission yeast centromeres.Semantic proximity Read ↗

Cleavage and polyadenylation factor, Rna14 is an essential protein required for the maintenance of genomic integrity in fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Semantic proximity Read ↗

Escape from Mitotic Arrest: An Unexpected Connection Between Microtubule Dynamics and Epigenetic Regulation of Centromeric Chromatin in Schizosaccharomyces pombe.Semantic proximity Read ↗

Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.Semantic proximity Read ↗

Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast.Semantic proximity Read ↗

A Dual Inhibitory Mechanism Sufficient to Maintain Cell-Cycle-Restricted CENP-A Assembly.Semantic proximity Read ↗

Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin.Semantic proximity Read ↗

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