Article
Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction.
PLoS genetics - 1 May 2014
Wain Louise V, Sayers Ian, Soler Artigas María, Portelli Michael A, Zeggini Eleftheria, Obeidat Ma'en, Sin Don D, Bossé Yohan, Nickle David, Brandsma Corry-Anke, Malarstig Anders, Vangjeli Ciara, Jelinsky Scott A, John Sally, Kilty Iain, McKeever Tricia, Shrine Nick R G, Cook James P, Patel Shrina, Spector Tim D, Hollox Edward J, Hall Ian P, Tobin Martin D
Abstract excerpt
Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality and, whilst smoking remains the single most important risk factor, COPD risk is heritable. Of 26 independent genomic regions showing association with lung function in genome-wide association studies, eleven have been reported to show association with airflow obstruction. Although the main risk factor for COPD is...
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