Article
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.
The Lancet. Respiratory medicine - 1 Oct 2015
Wain Louise V, Shrine Nick, Miller Suzanne, Jackson Victoria E, Ntalla Ioanna, Soler Artigas María, Billington Charlotte K, Kheirallah Abdul Kader, Allen Richard, Cook James P, Probert Kelly, Obeidat Ma'en, Bossé Yohan, Hao Ke, Postma Dirkje S, Paré Peter D, Ramasamy Adaikalavan, Mägi Reedik, Mihailov Evelin, Reinmaa Eva, Melén Erik, O'Connell Jared, Frangou Eleni, Delaneau Olivier, Freeman Colin, Petkova Desislava, McCarthy Mark, Sayers Ian, Deloukas Panos, Hubbard Richard, Pavord Ian, Hansell Anna L, Thomson Neil C, Zeggini Eleftheria, Morris Andrew P, Marchini Jonathan, Strachan David P, Tobin Martin D, Hall Ian P
Abstract excerpt
BACKGROUND: Understanding the genetic basis of airflow obstruction and smoking behaviour is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). We used UK Biobank data to study the genetic causes of smoking behaviour and lung health. METHODS: We sampled individuals of European ancestry from UK Biobank, from the middle and extremes of the forced expiratory volume in 1 s (FEV1)...
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