Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer.

doi:10.1016/j.jtho.2015.09.015

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Article

Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2016

Liu Yanhong, Kheradmand Farrah, Davis Caleb F, Scheurer Michael E, Wheeler David, Tsavachidis Spiridon, Armstrong Georgina, Simpson Claire, Mandal Diptasri, Kupert Elena, Anderson Marshall, You Ming, Xiong Donghai, Pikielny Claudio, Schwartz Ann G, Bailey-Wilson Joan, Gaba Colette, De Andrade Mariza, Yang Ping, Pinney Susan M, Amos Christopher I, Spitz Margaret R

Abstract excerpt

INTRODUCTION: The association between smoking-induced chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is well documented. Recent genome-wide association studies (GWAS) have identified 28 susceptibility loci for LC, 10 for COPD, 32 for smoking behavior, and 63 for pulmonary function, totaling 107 nonoverlapping loci. Given that common variants have been found to be associated with LC in...

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Identifiers

PMID: 26762739
DOI: 10.1016/j.jtho.2015.09.015
PMCID: PMC4714038

Genes

DBH
CHRNA5
CHRNB4
MAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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