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Article

Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease.

American journal of respiratory cell and molecular biology - 1 Nov 2018

Prokopenko Dmitry, Sakornsakolpat Phuwanat, Fier Heide Loehlein, Qiao Dandi, Parker Margaret M, McDonald Merry-Lynn N, Manichaikul Ani, Rich Stephen S, Barr R Graham, Williams Christopher J, Brantly Mark L, Lange Christoph, Beaty Terri H, Crapo James D, Silverman Edwin K, Cho Michael H

Abstract excerpt

Genome-wide association studies have identified common variants associated with chronic obstructive pulmonary disease (COPD). Whole-genome sequencing (WGS) offers comprehensive coverage of the entire genome, as compared with genotyping arrays or exome sequencing. We hypothesized that WGS in subjects with severe COPD and smoking control subjects with normal pulmonary function would allow us to identify novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29949718
DOI: 10.1165/rcmb.2018-0088OC
PMCID: PMC6236690

Genes

HHIP
SERPINA1
CHRNA5
SERPINA6
TNS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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