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Article

Understanding signatures of positive natural selection in human zinc transporter genes.

Scientific reports - 12 Mar 2022

Roca-Umbert Ana, Caro-Consuegra Rocio, Londono-Correa Diego, Rodriguez-Lozano Gabriel Felipe, Vicente Ruben, Bosch Elena

Abstract excerpt

Zinc is an essential micronutrient with a tightly regulated systemic and cellular homeostasis. In humans, some zinc transporter genes (ZTGs) have been previously reported as candidates for strong geographically restricted selective sweeps. However, since zinc homeostasis is maintained by the joint action of 24 ZTGs, other more subtle modes of selection could have also facilitated human adaptation to zinc...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35279701
DOI: 10.1038/s41598-022-08439-y
PMCID: PMC8918337

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