Article
Curcumin abolishes mutant TDP-43 induced excitability in a motoneuron-like cellular model of ALS.
Neuroscience - 11 Jul 2014
Dong H, Xu L, Wu L, Wang X, Duan W, Li H, Li C
Abstract excerpt
Mutation of TAR DNA-binding protein-43 (TDP-43) is detected in familial and sporadic amyotrophic lateral sclerosis (FALS and SALS). TDP-43-positive cytoplasmic inclusions are present in both neuron and glia of ALS, although not in mutant Cu/Zn-superoxide dismutase (mSOD1)-related or RNA binding protein Fused in sarcoma (FUS)-related ALS. Previous studies have established that cortical hyper-excitability is common...
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