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Article

Maturation and phenotype of pathophysiological neuronal excitability of human cells in tau-related dementia.

Journal of cell science - 27 May 2020

Kopach Olga, Esteras Noemí, Wray Selina, Rusakov Dmitri A, Abramov Andrey Y

Abstract excerpt

Frontotemporal dementia and parkinsonism (FTDP-17) caused by the 10+16 splice-site mutation in the gene encoding microtubule-associated protein tau (MAPT) provides an established platform to model tau-related dementia in vitro Neurons derived from human induced pluripotent stem cells (iPSCs) have been shown to recapitulate the neurodevelopmental profile of tau pathology during in vitro corticogenesis, as in the...

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Identifiers

PMID: 32299835
DOI: 10.1242/jcs.241687
PMCID: PMC7272359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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