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Article

Neurodegeneration induced by complex I inhibition in a cellular model of familial amyotrophic lateral sclerosis.

Brain research bulletin - 28 Apr 2006

Rizzardini Milena, Lupi Monica, Mangolini Alessandra, Babetto Elisabetta, Ubezio Paolo, Cantoni Lavinia

Abstract excerpt

G93A Cu/Zn superoxide dismutase (SOD1), a human mutant SOD1 associated with familial amyotrophic lateral sclerosis, increased the toxicity of the mitochondrial toxin rotenone in the NSC-34 motoneuronal cell line. G93ASOD1 cells died more than untransfected and wild-type SOD1 cells after 6 and 24h exposure to 12.5 microM rotenone. Biparametric flow cytometry showed that rotenone induced rapid hyperpolarization of...

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Identifiers

PMID: 16624679
DOI: 10.1016/j.brainresbull.2006.02.013

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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