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Article

The effect of amyotrophic lateral sclerosis-linked exogenous SOD1-G93A on electrophysiological properties and intracellular calcium in cultured rat astrocytes.

Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Jan 2000

Milošević Milena, Bataveljić Danijela, Nikolić Ljiljana, Bijelić Dunja, Andjus Pavle

Abstract excerpt

Over 150 mutations in the SOD1 gene that encodes Cu/Zn superoxide dismutase (SOD1) cause 20-25% of familial ALS, albeit without a known gain-of-function mechanism. ALS is also non-cell-autonomous, the interactions between motor neurons and their glial neighbours being implicated in disease progression. The aim here was to investigate the biophysical effects of the exogenous human mutant SOD1-G93A on rat...

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Identifiers

PMID: 26892977
DOI: 10.3109/21678421.2016.1143516

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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