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Article

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo.

Molecular neurodegeneration - 8 May 2017

Kawamata Hibiki, Peixoto Pablo, Konrad Csaba, Palomo Gloria, Bredvik Kirsten, Gerges Meri, Valsecchi Federica, Petrucelli Leonard, Ravits John M, Starkov Anatoly, Manfredi Giovanni

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Functional studies of mitochondrial bioenergetics have focused mostly on superoxide dismutase 1 (SOD1) mutants, and showed that mutant human SOD1 impairs mitochondrial oxidative phosphorylation, calcium homeostasis, and dynamics. However, recent reports...

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Identifiers

PMID: 28482850
DOI: 10.1186/s13024-017-0180-1
PMCID: PMC5422931

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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