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Article

TRAF5 is a downstream target of MAVS in antiviral innate immune signaling.

PloS one - 11 Feb 2010

Tang Eric D, Wang Cun-Yu

Abstract excerpt

The recognition of nucleic acids by the innate immune system during viral infection results in the production of type I interferons and the activation of antiviral immune responses. The RNA helicases RIG-I and MDA-5 recognize distinct types of cytosolic RNA species and signal through the mitochondrial protein MAVS to stimulate the phosphorylation and activation of the transcription factors IRF3 and IRF7, thereby...

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Source

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Identifiers

PMID: 20161788
DOI: 10.1371/journal.pone.0009172
PMCID: PMC2820086

Genes

MAVS
TRAF5
TRAF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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