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Article

Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African Americans.

Arthritis & rheumatology (Hoboken, N.J.) - 1 May 2014

Dong Chaoling, Ptacek Travis S, Redden David T, Zhang Kui, Brown Elizabeth E, Edberg Jeffrey C, McGwin Gerald, Alarcón Graciela S, Ramsey-Goldman Rosalind, Reveille John D, Vilá Luis M, Petri Michelle, Qin Aijian, Wu Jianming, Kimberly Robert P

Abstract excerpt

OBJECTIVE: To investigate whether the Fcγ receptor IIIa-66L/R/H (FcγRIIIa-66L/R/H) polymorphism influences net effective receptor function and to assess if the FCGR3A combined genotypes formed by FcγRIIIa-66L/R/H and FcγRIIIa-176F/V, as well as copy number variation (CNV), confer risk of developing systemic lupus erythematosus (SLE) and lupus nephritis. METHODS: FcγRIIIa variants, expressed on A20 IIA1.6 cells,...

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Identifiers

PMID: 24782186
DOI: 10.1002/art.38337
PMCID: PMC4069204

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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