Article
Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.
Rheumatology (Oxford, England) - 1 May 2016
Tsang-A-Sjoe Michel W P, Nagelkerke Sietse Q, Bultink Irene E M, Geissler Judy, Tanck Michael W T, Tacke Carline E, Ellis Justine A, Zenz Werner, Bijl Marc, Berden Johannes H, de Leeuw Karina, Derksen Ronald H, Kuijpers Taco W, Voskuyl Alexandre E
Abstract excerpt
OBJECTIVE: To determine relevant Fc-gamma receptor (FcγR) polymorphisms in relation to susceptibility to SLE and LN, and to determine the functional consequences of genetic associations found. METHODS: Using multiplex ligation-dependent probe amplification, copy number regions (CNRs) and relevant known functional single nucleotide polymorphisms of FcγRII and FcγRIII were determined in a LN-enriched cohort of 266...
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