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Article

Evidence against a beneficial effect of irisin in humans.

PloS one - 1 Jan 2013

Raschke Silja, Elsen Manuela, Gassenhuber Hans, Sommerfeld Mark, Schwahn Uwe, Brockmann Barbara, Jung Raphael, Wisløff Ulrik, Tjønna Arnt E, Raastad Truls, Hallén Jostein, Norheim Frode, Drevon Christian A, Romacho Tania, Eckardt Kristin, Eckel Juergen

Abstract excerpt

Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing browning of white fat cells, which improves systemic metabolism by increasing energy expenditure in mice. The discovery of irisin raised expectations of its therapeutic potential to treat metabolic diseases. However, the effect of...

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Identifiers

PMID: 24040023
DOI: 10.1371/journal.pone.0073680
PMCID: PMC3770677

Genes

FNDC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Evidence against a beneficial effect of irisin in humans.PMID 24040023Read ↗

Browning of white fat: does irisin play a role in humans?Semantic proximity Read ↗

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin ResistanceSemantic proximity Read ↗

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humansSemantic proximity Read ↗

Progress and Challenges in the Biology of FNDC5 and IrisinSemantic proximity Read ↗

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic reviewSemantic proximity Read ↗

Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.Semantic proximity Read ↗

Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative DiseasesSemantic proximity Read ↗

Irisin, Energy Homeostasis and Male ReproductionSemantic proximity Read ↗

Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women.Semantic proximity Read ↗

Association of metabolic parameters and rs726344 in FNDC5 with serum irisin concentrations.Semantic proximity Read ↗

Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling.Semantic proximity Read ↗

Can Resistance Exercise Alter Irisin Levels and Expression Profiles of FNDC5 and UCP1 in Rats?Semantic proximity Read ↗

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