Article
Polymorphisms in BMP2/BMP4, with estimates of mean lung dose, predict radiation pneumonitis among patients receiving definitive radiotherapy for non-small cell lung cancer.
Oncotarget - 27 Jun 2017
Yang Ju, Xu Ting, Gomez Daniel R, Yuan Xianglin, Nguyen Quynh-Nhu, Jeter Melenda, Song Yipeng, Hahn Stephen, Liao Zhongxing
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in TGFβ1 can predict the risk of radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) after definitive radiotherapy. Here we investigated whether SNPs in TGFβ superfamily members BMP2 and BMP4 are associated with RP in such patients. In total, we retrospectively analyzed 663 patients given ≥ 60 Gy for NSCLC. We randomly assigned 323 patients to the...
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