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Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution

28 Apr 2014

Abstract excerpt

The newly emerging Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes a Severe Acute Respiratory Syndrome-like disease with ∼43% mortality. Given the recent detection of virus in dromedary camels, zoonotic transfer of MERS-CoV to humans is suspected. In addition, little is known about the role of human neutralizing Ab (nAb) pressure as a driving force in MERS-CoV adaptive evolution. Here, we used a...

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PMID: 24778221
DOI: 10.1073/pnas.1402074111

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