Article

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody

2021-04-08

Abstract excerpt

The recent emergence of SARS-CoV-2 variants of concern (VOC) and the recurrent spillovers of coronaviruses in the human population highlight the need for broadly neutralizing antibodies that are not affected by the ongoing antigenic drift and that can prevent or treat future zoonotic infections. Here, we describe a human monoclonal antibody (mAb), designated S2×259, recognizing a highly conserved cryptic receptor-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 159c0ee1-5215-5d9d-8f5b-f2a8419c0393
DOI: 10.1101/2021.04.07.438818

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibodyDOI 10.1101/2021.04.07.438818Read

Broad sarbecovirus neutralization by a human monoclonal antibody.Semantic proximity Read

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domainSemantic proximity Read

A human monoclonal antibody neutralizing SARS-CoV-2 Omicron variants containing the L452R mutation.Semantic proximity Read

A human monoclonal antibody targeting a conserved pocket in the SARS-CoV-2 receptor-binding domain coreSemantic proximity Read

A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinerySemantic proximity Read

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infectionSemantic proximity Read

Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variantsSemantic proximity Read

Broad Neutralization Activity of SARS-CoV-2 Antibody is Achieved by Coordinated Recognition of Virus Vulnerable SiteSemantic proximity Read

The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against viral variantsSemantic proximity Read

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infectionSemantic proximity Read

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecovirusesSemantic proximity Read

A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversificationSemantic proximity Read