Article

Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal models

2020-05-14

Abstract excerpt

Effective therapies are urgently needed for the SARS-CoV-2/COVID19 pandemic. We identified panels of fully human monoclonal antibodies (mAbs) from eight large phage-displayed Fab, scFv and VH libraries by panning against the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein. One high affinity mAb, IgG1 ab1, specifically neutralized replication competent SARS-CoV-2 with exceptional potency as m...

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Literature Corpus work: fbdce2f1-7d00-58a6-851d-b5d871e9c9d7
DOI: 10.1101/2020.05.13.093088

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