Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection

2 Nov 2020

Abstract excerpt

Effective therapies are urgently needed for the SARS-CoV-2/COVID-19 pandemic. We identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed Fab, scFv, and VH libraries by panning against the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein. A high-affinity Fab was selected from one of the libraries and converted to a full-size antibody, IgG1 ab1, which competed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Monoclonal and Polyclonal Antibodies Research
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33139569
DOI: 10.1073/pnas.2010197117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infectionPMID 33139569Read ↗

Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal modelsSemantic proximity Read ↗

Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylacticsSemantic proximity Read ↗

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variantsSemantic proximity Read ↗

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibodySemantic proximity Read ↗

High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models.Semantic proximity Read ↗

Fully human single-domain antibodies against SARS-CoV-2Semantic proximity Read ↗

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralizationSemantic proximity Read ↗

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaquesSemantic proximity Read ↗

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domainSemantic proximity Read ↗

Broad Neutralization Activity of SARS-CoV-2 Antibody is Achieved by Coordinated Recognition of Virus Vulnerable SiteSemantic proximity Read ↗

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades agoSemantic proximity Read ↗

A human monoclonal antibody targeting a conserved pocket in the SARS-CoV-2 receptor-binding domain coreSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.