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Article

Fully human single-domain antibodies against SARS-CoV-2

2020-03-31

Abstract excerpt

The COVID-19 pandemic is spreading rapidly, highlighting the urgent need for an efficient approach to rapidly develop therapeutics and prophylactics against SARS-CoV-2. We describe here the development of a phage-displayed single-domain antibody library by grafting naïve CDRs into framework regions of an identified human germline IGHV allele. This enabled the isolation of high-affinity single-domain antibodies of...

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Identifiers and source

Literature Corpus work
c1552575-5b74-562e-b816-aa24e0e18167
DOI
10.1101/2020.03.30.015990
Open publication

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Fully human single-domain antibodies against SARS-CoV-2DOI 10.1101/2020.03.30.015990
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