Article
Structure of the branched intermediate in protein splicing.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2014
Liu Zhihua, Frutos Silvia, Bick Matthew J, Vila-Perelló Miquel, Debelouchina Galia T, Darst Seth A, Muir Tom W
Abstract excerpt
Inteins are autoprocessing domains that cut themselves out of host proteins in a traceless manner. This process, known as protein splicing, involves multiple chemical steps that must be coordinated to ensure fidelity in the process. The committed step in splicing involves attack of a conserved Asn side-chain amide on the adjacent backbone amide, leading to an intein-succinimide product and scission of that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.