Article
The mechanism of protein splicing and its modulation by mutation.
The EMBO journal - 1 Oct 1996
Xu M Q, Perler F B
Abstract excerpt
Protein splicing results in the expression of two mature proteins from a single gene. After synthesis of a precursor protein, an internal segment (the intein) is excised and the external domains are joined together. A self-catalyzed mechanism for this cleavage-ligation reaction is presented, base...
Topics
- Bacterial Proteins
- Carrier Proteins
- Cysteine
- DNA-Directed DNA Polymerase
- Hydroxylamine
- Hydroxylamines
- Maltose-Binding Proteins
- Models, Genetic
- Mutagenesis, Insertional
- Mutation
- Protein Precursors
- Protein Splicing
- Recombinant Proteins
- Tropomyosin