Article
An alternative protein splicing mechanism for inteins lacking an N-terminal nucleophile.
The EMBO journal - 15 Sept 2000
Southworth M W, Benner J, Perler F B
Abstract excerpt
Variations in the intein-mediated protein splicing mechanism are becoming more apparent as polymorphisms in conserved catalytic residues are identified. The conserved Ser or Cys at the intein N-terminus and the conserved intein penultimate His are absent in the KlbA family of inteins. These inteins were predicted to be inactive, since an N-terminal Ala cannot perform the initial reaction of the standard protein...
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