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Article

Haptoglobin genotype-dependent differences in macrophage lysosomal oxidative injury.

The Journal of biological chemistry - 6 Jun 2014

Asleh Rabea, Ward John, Levy Nina S, Safuri Shady, Aronson Doron, Levy Andrew P

Abstract excerpt

The major function of the Haptoglobin (Hp) protein is to control trafficking of extracorpuscular hemoglobin (Hb) thru the macrophage CD163 receptor with degradation of the Hb in the lysosome. There is a common copy number polymorphism in the Hp gene (Hp 2 allele) that has been associated with a severalfold increased incidence of atherothrombosis in multiple longitudinal studies. Increased plaque oxidation and...

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Identifiers

PMID: 24778180
DOI: 10.1074/jbc.M114.554212
PMCID: PMC4047400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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