Article
Haptoglobin polymorphism and body iron stores.
Clinical chemistry and laboratory medicine - 1 Mar 2002
Delanghe Joris R, Langlois Michel R
Abstract excerpt
In humans the iron status is influenced by environmental and genetic factors. Among them, the genetic polymorphism of the hemoglobin (Hb)-binding plasma protein haptoglobin (Hp) has been shown to affect iron turnover. The best known biological function of Hp is capture of free Hb in plasma to allow hepatic recycling of heme iron and to prevent kidney damage during hemolysis. In healthy males, but not in females,...
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