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Article

Poor lysosomal membrane integrity in proximal tubule cells of haptoglobin 2-2 genotype mice with diabetes mellitus.

Free radical biology & medicine - 15 Aug 2012

Asleh Rabea, Nakhoul Farid M, Miller-Lotan Rachel, Awad Hoda, Farbstein Dan, Levy Nina S, Nakhoul Nakhoul, Iancu Theodore C, Manov Irena, Laue Michael, Traber Maret G, Lebold Katie M, Levy Andrew P

Abstract excerpt

The haptoglobin (Hp) genotype is a major determinant of progression of nephropathy in individuals with diabetes mellitus (DM). The major function of the Hp protein is to bind and modulate the fate of extracorpuscular hemoglobin and its iron cargo. We have previously demonstrated an interaction between the Hp genotype and the DM on the accumulation of iron in renal proximal tubule cells. The primary objective of...

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Share to beta-N-Acetylhexosaminidases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kidney Tubules, Proximal

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Identifiers

PMID: 22749805
DOI: 10.1016/j.freeradbiomed.2012.06.015
PMCID: PMC3600120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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