Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+Macrophages

1 Jan 2013

Abstract excerpt

Intraplaque hemorrhage causes adaptive remodelling of macrophages towards a protective phenotype specialized towards handling iron and lipid overload, denoted Mhem. The Mhem phenotype expresses elevated levels of hemoglobin (Hb) scavenger receptor, CD163, capable of endocytosing pro-oxidant free Hb complexed to acute phase protein haptoglobin (Hp). It is notable that individuals homozygous for the Hp 2 allele (a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocyte Function and Pathophysiology
Share to Heme Oxygenase-1 and Carbon Monoxide
Share to Hemoglobin structure and function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23710416
DOI: 10.1155/2013/980327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haptoglobin Genotype-Dependent Anti-Inflammatory Signaling in CD163+MacrophagesPMID 23710416Read ↗

Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability.Semantic proximity Read ↗

Unlocking the link between haptoglobin polymorphism and noninfectious human diseases: insights and implications.Semantic proximity Read ↗

CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.Semantic proximity Read ↗

Intraplaque hemorrhage.Semantic proximity Read ↗

Genotype-dependent impairment of hemoglobin clearance increases oxidative and inflammatory response in human diabetic atherosclerosis.Semantic proximity Read ↗

Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype.Semantic proximity Read ↗

Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases.Semantic proximity Read ↗

Pathophysiological relevance of macrophage subsets in atherogenesis.Semantic proximity Read ↗

Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque.Semantic proximity Read ↗

Haptoglobin genotype-dependent differences in macrophage lysosomal oxidative injury.Semantic proximity Read ↗

Regulation of CD163 associated casein kinase II activity is haptoglobin genotype dependent.Semantic proximity Read ↗

In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.