Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis.

doi:10.1016/j.jacc.2012.04.011

Article

Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis.

Journal of the American College of Cardiology - 10 Jul 2012

Purushothaman K-Raman, Purushothaman Meerarani, Levy Andrew P, Lento Patrick A, Evrard Solene, Kovacic Jason C, Briley-Saebo Karen C, Tsimikas Sotirios, Witztum Joseph L, Krishnan Prakash, Kini Annapoorna, Fayad Zahi A, Fuster Valentin, Sharma Samin K, Moreno Pedro R

Abstract excerpt

OBJECTIVES: The purpose of this study was to test the hypothesis that increased oxidative stress is associated with apoptosis in human plaques with the haptoglobin (Hp) 2-2 genotype. BACKGROUND: Intraplaque hemorrhage releases free hemoglobin (Hb). Impaired Hb clearance induces oxidative stress leading to plaque progression. The binding of Hp to Hb attenuates iron-induced oxidative reactions. METHODS: Twenty-six...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis.

Abstract excerpt

Topics

Related research