Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease.

Vascular health and risk management - 1 Jan 2005

Asleh Rabea, Levy Andrew P

Abstract excerpt

Hemoglobin (Hb) released during hemolysis is a potent oxidant. Extracorpuscular Hb may enter the vessel wall and mediate low-density lipoprotein oxidation, thereby promoting the development and progression of atherosclerosis. Haptoglobin (Hp) is an antioxidant protein as a result of its ability to bind Hb and block Hb-induced oxidative damage. Hp also facilitates the removal of Hb from the extravascular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, Myelomonocytic
Share to CD163 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Restenosis

Share to Diabetic Angiopathies

Share to Diabetic Retinopathy

Share to Haptoglobins

Share to Lipoproteins, LDL

Share to Patient Selection

Source

Open in PubMed Open full text

Identifiers

PMID: 17319095
DOI: 10.2147/vhrm.1.1.19.58930
PMCID: PMC1993923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease.PMID 17319095Read ↗

Genotype-dependent impairment of hemoglobin clearance increases oxidative and inflammatory response in human diabetic atherosclerosis.Semantic proximity Read ↗

The protean role of haptoglobin and haptoglobin genotypes on vascular complications in diabetes mellitus.Semantic proximity Read ↗

Haptoglobin: basic and clinical aspects.Semantic proximity Read ↗

Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease.Semantic proximity Read ↗

Unlocking the link between haptoglobin polymorphism and noninfectious human diseases: insights and implications.Semantic proximity Read ↗

Hypothesis--haptoglobin genotype and diabetic nephropathy.Semantic proximity Read ↗

Is it time to screen for the haptoglobin genotype to assess the cardiovascular risk profile and vitamin E therapy responsiveness in patients with diabetes?Semantic proximity Read ↗

Haptoglobin genotype and its role in determining heme-iron mediated vascular disease.Semantic proximity Read ↗

Haptoglobin genotype and its role in diabetic cardiovascular disease.Semantic proximity Read ↗

Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases.Semantic proximity Read ↗

[HAPTOGLOBIN POLYMORPHISM AS AN INDEPENDENT PREDICTOR OF DIABETIC NEPHROPATHY AND RETINOPATHY].Semantic proximity Read ↗

Haptoglobin phenotypes in health and disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.