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Article

Catechol-O-methyltransferase (COMT) genotype affects age-related changes in plasticity in working memory: a pilot study.

BioMed research international - 1 Jan 2014

Heinzel Stephan, Riemer Thomas G, Schulte Stefanie, Onken Johanna, Heinz Andreas, Rapp Michael A

Abstract excerpt

OBJECTIVES: Recent work suggests that a genetic variation associated with increased dopamine metabolism in the prefrontal cortex (catechol-O-methyltransferase Val158Met; COMT) amplifies age-related changes in working memory performance. Research on younger adults indicates that the influence of d...

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Identifiers

PMID: 24772423
DOI: 10.1155/2014/414351
PMCID: PMC3977538

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24772423-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Catechol-O-methyltransferase (COMT) genotype affects age-related changes in plasticity in working memory: a pilot study.PMID 24772423Read ↗

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COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.Semantic proximity Read ↗

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Effect of COMT Val158Met polymorphism on the Continuous Performance Test, Identical Pairs Version: tuning rather than improving performance.Semantic proximity Read ↗

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