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Article

Effect of COMT Val158Met polymorphism on the Continuous Performance Test, Identical Pairs Version: tuning rather than improving performance.

The American journal of psychiatry - 1 Sept 2005

Stefanis Nicholas C, van Os Jim, Avramopoulos Dimitrios, Smyrnis Nikolaos, Evdokimidis Ioannis, Stefanis Costas N

Abstract excerpt

OBJECTIVE: It has been suggested that variation in catechol O-methyltransferase (COMT) activity associated with variation in COMT Val158Met genotypes may result in enhanced or reduced cognitive performance, depending on whether the phenotype requires cognitive stability or cognitive flexibility....

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Source

Identifiers

PMID: 16135641
DOI: 10.1176/appi.ajp.162.9.1752

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16135641-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Effect of COMT Val158Met polymorphism on the Continuous Performance Test, Identical Pairs Version: tuning rather than improving performance.PMID 16135641Read ↗

COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination.Semantic proximity Read ↗

The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: evidence for a role of dopamine in the control of task-switching.Semantic proximity Read ↗

Genes, cognition and brain through a COMT lens.Semantic proximity Read ↗

COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.Semantic proximity Read ↗

Associations between COMTVal158Met polymorphism and cognition: direct or indirect effects?Semantic proximity Read ↗

Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility.Semantic proximity Read ↗

COMT Val158Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase InhibitionSemantic proximity Read ↗

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.Semantic proximity Read ↗

Association between executive functions and COMT Val108/158Met polymorphism among healthy younger and older adults: A preliminary study.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) val158met genotype is associated with BOLD response as a function of task characteristic.Semantic proximity Read ↗

Effect of COMT val158met genotype on cognition and personality.Semantic proximity Read ↗

COMT Val 158 Met polymorphism is associated with cognitive flexibility in a signal discrimination task in schizophrenia.Semantic proximity Read ↗

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