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Article

Effect of COMT Val158Met polymorphism on the Continuous Performance Test, Identical Pairs Version: tuning rather than improving performance.

The American journal of psychiatry - 1 Sept 2005

Stefanis Nicholas C, van Os Jim, Avramopoulos Dimitrios, Smyrnis Nikolaos, Evdokimidis Ioannis, Stefanis Costas N

Abstract excerpt

OBJECTIVE: It has been suggested that variation in catechol O-methyltransferase (COMT) activity associated with variation in COMT Val158Met genotypes may result in enhanced or reduced cognitive performance, depending on whether the phenotype requires cognitive stability or cognitive flexibility. The authors' goal was to determine whether, in confirmation of this prediction, performance on a measure of cognitive...

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Source

Identifiers

PMID: 16135641
DOI: 10.1176/appi.ajp.162.9.1752

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of COMT Val158Met polymorphism on the Continuous Performance Test, Identical Pairs Version: tuning rather than improving performance.PMID 16135641Read ↗

COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination.Semantic proximity Read ↗

The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: evidence for a role of dopamine in the control of task-switching.Semantic proximity Read ↗

Genes, cognition and brain through a COMT lens.Semantic proximity Read ↗

COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.Semantic proximity Read ↗

Associations between COMTVal158Met polymorphism and cognition: direct or indirect effects?Semantic proximity Read ↗

Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility.Semantic proximity Read ↗

COMT Val158Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase InhibitionSemantic proximity Read ↗

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.Semantic proximity Read ↗

Association between executive functions and COMT Val108/158Met polymorphism among healthy younger and older adults: A preliminary study.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) val158met genotype is associated with BOLD response as a function of task characteristic.Semantic proximity Read ↗

Effect of COMT val158met genotype on cognition and personality.Semantic proximity Read ↗

COMT Val 158 Met polymorphism is associated with cognitive flexibility in a signal discrimination task in schizophrenia.Semantic proximity Read ↗

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