Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

COMT polymorphism and memory dedifferentiation in old age.

Psychology and aging - 1 Jun 2014

Papenberg Goran, Bäckman Lars, Nagel Irene E, Nietfeld Wilfried, Schröder Julia, Bertram Lars, Heekeren Hauke R, Lindenberger Ulman, Li Shu-Chen

Abstract excerpt

According to a neurocomputational theory of cognitive aging, senescent changes in dopaminergic modulation lead to noisier and less differentiated processing. The authors tested a corollary hypothesis of this theory, according to which genetic predispositions of individual differences in prefrontal dopamine (DA) signaling may affect associations between memory functions, particularly in old age. Latent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dopamine
Share to Memory
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Memory, Episodic

Share to Memory, Short-Term

Share to Methionine

Share to Prefrontal Cortex

Share to Valine

Source

Identifiers

PMID: 23834492
DOI: 10.1037/a0033225

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COMT polymorphism and memory dedifferentiation in old age.PMID 23834492Read ↗

Healthy aging increases the cognitive effects of two genes that influence extracellular dopamine.Semantic proximity Read ↗

Catechol-o-methyl transferase modulates cognition in late life: evidence and implications for cognitive enhancement.Semantic proximity Read ↗

Association between executive functions and COMT Val108/158Met polymorphism among healthy younger and older adults: A preliminary study.Semantic proximity Read ↗

Dopamine-related polymorphisms and Affective Working Memory in aging.Semantic proximity Read ↗

Lack of association between COMT and working memory in a population-based cohort of healthy young adults.Semantic proximity Read ↗

The COMTp.Val158Met Polymorphism and Cognitive Performance in Adult Development, Healthy Aging and Mild Cognitive Impairment.Semantic proximity Read ↗

Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population.Semantic proximity Read ↗

COMT genotype and cognitive ability: a longitudinal aging study.Semantic proximity Read ↗

The functional COMT polymorphism, Val158Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year oldsSemantic proximity Read ↗

Sex-dichotomous effects of functional COMT genetic variations on cognitive functions disappear after menopause in both health and schizophrenia.Semantic proximity Read ↗

Genetic and vascular modifiers of age-sensitive cognitive skills: effects of COMT, BDNF, ApoE, and hypertension.Semantic proximity Read ↗

COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.