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Article

Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.

The Journal of cell biology - 15 Feb 2016

Liu An, Zhou Zikai, Dang Rui, Zhu Yuehua, Qi Junxia, He Guiqin, Leung Celeste, Pak Daniel, Jia Zhengping, Xie Wei

Abstract excerpt

Neuroligin (NLG) 1 is important for synapse development and function, but the underlying mechanisms remain unclear. It is known that at least some aspects of NLG1 function are independent of the presynaptic neurexin, suggesting that the C-terminal domain (CTD) of NLG1 may be sufficient for synaptic regulation. In addition, NLG1 is subjected to activity-dependent proteolytic cleavage, generating a cytosolic CTD...

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Share to Actin Cytoskeleton
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Adhesion Molecules, Neuronal

Share to Dendritic Spines

Share to GTPase-Activating Proteins

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Source

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Identifiers

PMID: 26880202
DOI: 10.1083/jcb.201509023
PMCID: PMC4754719

Genes

LIMK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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