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Article

<scp>PI</scp>3K‐dependent multiple myeloma cell survival is mediated by the <scp>PIK</scp>3<scp>CA</scp> isoform

26 Apr 2014

Abstract excerpt

Constitutive phosphatidylinositide 3-kinase (PI3K) signalling has been implicated in multiple myeloma (MM) pathophysiology and is regarded as an actionable target for pharmacological intervention. Isoform-specific PI3K inhibition may offer the most focused treatment approach and could result in greater clinical efficacy and reduced side effects. We therefore performed isoform-specific knockdown of PIK3CA, PIK3CB,...

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PMID: 24766330
DOI: 10.1111/bjh.12920

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