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Article

Growth control of multiple myeloma cells through inhibition of glycogen synthase kinase-3

1 Jan 2008

Abstract excerpt

Anti-apoptotic pathways play a central role in the survival of multiple myeloma cells. The contribution of PI3-kinase and Akt kinase in mediating myeloma cell survival is well established although the role of glycogen synthase kinase-3 (GSK3) is less defined. In this study we determined the contribution of GSK3 in growth regulation of myeloma cells. We treated six different multiple myeloma cell lines with a...

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PMID: 18728964
DOI: 10.1080/10428190802304966

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