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Article

Gene of the month: PIK3CA.

Journal of clinical pathology - 1 Apr 2015

Lai K, Killingsworth M C, Lee C S

Abstract excerpt

PIK3CA encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) which through its role in the PI3K/Akt pathway is important for the regulation of important cellular functions such as proliferation, metabolism and protein synthesis, angiogenesis and apoptosis. Mutations in PIK3CA are known to be involved in a wide range of human cancers and mutant PIK3CA is thought to act as an oncogene. The...

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Source

Identifiers

PMID: 25688137
DOI: 10.1136/jclinpath-2015-202885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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